Questions about clomiphene

What is clomiphene (clomiphene sirat) Translation from the american site.
clomiphene (or clomiphene sirat) is a synthetic drug that prevents the effects of estrogen on the brain. Due to the brain increases the stimulation of the ovaries, which, in turn, leads to increased levels of estrogen and likelihood of ovulation. There are two trademarks citrate: Clomid (Ok) is available Merrell-the Dow and Serophene (Serofen), the producer by serono. Both of these product are medical counterparts, although Serofen is cheaper. There are also several generic drug (generic forms) citrate, which cost significantly less (Klostilbegit).
For what used clomiphene?

clomiphene is mainly used to stimulate ovulation. Many women who do not ovulate, with the help of the reception citrate can start ovulated.
Is appointed if clomiphene women with ovulation occurs naturally?

clomiphene can be assigned to women, ovulate a natural way, to increase the chances of achieving pregnancy.
Weakens whether clomiphene fertility?

Antiestrogenic effect citrate may provoke thicken the cervical mucus. This may, in turn hinder the promotion of sperm to the egg. Treatment may include artificial (a vaginal insemination) and, in rare cases, external control / impact on the level of estrogen.
clomiphene can also lead to thinning of the endometrium, which is an adverse factor for the implantation of the embryo. If ULTRASOUND defines a thin uterine lining, it can be treated with other drugs that stimulate ovulation.
When taking clomiphene?

clomiphene usually take daily a tablet, or 50 mg for 5 days. Treatment is usually started with 2-5 days of the cycle (the first day of the cycle is the first day of bleeding) are Now increasingly prescribed the drug with the 2-nd day of the cycle.
As regulated by the dose of citrate?

Women usually start with 50 mg daily for 5 days. If ovulation occurs, but pregnancy from the first cycle does not occur, the treatment of klomifenom can be repeated in the same dosage in the period of 3-6 cycles. If ovulation during the initial dosage does not occur, the dose may be increased to two tablets within 5 days of the next cycle.
The use of citrate in a designated dosage may be repeated only from 3 to 6 cycles. Maximum dose of citrate is 150 mg, or three tablets daily for five days. In rare cases, can be assigned to four pills, or 200 mg per day.
How to define ovulation?

There are several different ways of determining ovulation. Methods commonly used definitions of the basal temperature, the surge of LH, endometrial biopsy, the determination of the level of progesterone or transvaginal ultrasound study of the development of the follicles. Each of these methods has its advantages and disadvantages, and none of these methods can not reliably determine-whether there was an ovulation.
What to do when the two peaks of the LH?

clomiphene increases the likelihood of false peaks of LH in several days after the termination of course of treatment Klomifenom. Since the reception of the drug, as a rule, appointed with 5-th to 9-th days of the cycle, the color change on the test ovulation on the 11th day may be incorrectly interpreted.
Determined that the majority of women ovulate on 7-10 day after taking the last pill (this corresponds to the 16-19th day of the cycle with a view of the start of the reception Citrate from 5-th to 9-th days of the cycle)
When doing the test the progesterone?

Usually the analysis of the blood on the progesterone are doing in 7 days after the expected date of ovulation. In women with a 28-day cycle, this will be for 21 days. In women with more dlinnyi or short-cycle of the best time for analysis of the blood on the progesterone is usually within 7 days before the expected start of the next menstrual period.
Test the progesterone can also be placed on the 5-7 day after the jump basal temperature or on the 9th day after the change of color of the stripes on the home tester, or by the testimony of ULTRASOUND.
If day, calculated for the test, falls on a Sunday or holiday, then the test, you can move to the previous or next days.
That means "good" analysis of progesterone?

Progesterone level from 10 to 15 or above, be regarded as satisfactory. If progesterone levels below, it may be necessary to increase the dose of citrate or receiving other preparartov that stimulate ovulation, as well as progesterone drugs.
How to use home test (LH)?

Brain produces lyuteinostimuliruyuschy hormone (LH), which is responsible for ovulation. Leap in the level of LH is usually between 12 and 16 days of the cycle. LH can be determined with the help of home test: every morning, starting at around 9-th day, ie for 2-3 days before the jump LH, you should make a test.
Ovulation should occur through 12-36 hours after the change of the color bars. Slight change of colour strips may indicate a false or premature leap.
What are my chances of conceiving after taking citrate?

Chances of conceiving on a background of reception citrate amount to 10-13% per cycle of treatment depending on age, cause of infertility, the reaction of the organism to the treatment and other drugs, which are used at the same time with klomifenom. This compares with 20% for women with normal fertility. The possibility of conception grows up to 30-60% after six cycles reception citrate.
What are the chances of a multiple pregnancy on a background of reception citrate?

About 5-10% of pregnancies that occurred when receiving citrate end with the birth of twins and less than 1% - the birth of three or more children. This equates to 1.2% of twins born to women who are not taking clomiphene.
Whether clomiphene cause any abnormality of the fetus?

clomiphene is used in the united states since 1967. To date there is no evidence that clomiphene increases the probability of a birth of children with disabilities and or affect the development of children.